Matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is associated with nasopharyngeal carcinoma (NPC) risk
نویسندگان
چکیده
منابع مشابه
Lack of association between matrix metalloproteinase-1 (MMP-1) promoter polymorphism and risk of renal cell carcinoma.
OBJECTIVE Investigate the possible association of insertion/deletion (2G/G) polymorphism at nucleotide -1607 of the MMP-1 promoter with the development and progression of renal cancer. MATERIALS AND METHODS In this study, we genotyped 217 individuals, 99 patients with renal cell carcinoma (RCC) and 118 controls without cancer. DNA specimens were extracted from epithelial buccal cells and para...
متن کاملRapid communication: a BstXI polymorphism in the porcine matrix metalloproteinase 1 (MMP-1) gene locus.
1This project is supported by grants from the National Natural Science Foundation of China; Ministry of Agriculture, China, and Sino-German Agricultural Cooperation Program. 2Present address: Centre for Genetic Improvement of Livestock, Dept. of Anim. and Poult. Sci., Univ. of Guelph, Guelph, Ontario N1G 2W1 Canada. 3To whom correspondence should be addressed (phone: 08161 71 3746; E-mail: rott...
متن کاملA single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes.
Interstitial collagen gives fetal membranes tensile strength, and membrane rupture has been attributed to collagen degradation. A polymorphism at -1607 in the matrix metalloproteinase-1 (MMP-1) promoter (an insertion of a guanine (G)) creates a core Ets binding site and increases promoter activity. We investigated whether this polymorphism is functionally significant for MMP-1 expression in amn...
متن کاملMCP-1 Promoter Polymorphism at 2518 is associated with metastasis of nasopharyngeal carcinoma after treatment.
PURPOSE We herein examined whether the single nucleotide polymorphism (SNP) at -2518 of the MCP-1 gene promoter region influences clinical outcomes among nasopharyngeal carcinoma (NPC) patients. EXPERIMENTAL DESIGN The study population consisted of 411 NPC patients without metastasis at diagnosis. All patients were treated at the Chang Gung Memorial Hospital from March 1994 to November 2004. ...
متن کاملExpression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.
Membrane type 1 matrix metalloproteinase (MT1-MMP) is frequently expressed by cancer cells and is believed to play an important role in cancer cell invasion and metastasis. However, little is known about the role of MT1-MMP in mediating invasiveness of cervical cancer cells. In this study, we examined MT1-MMP expression in 58 primary human cervical tissue specimens, including normal cervix, low...
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ژورنال
عنوان ژورنال: Cellular and Molecular Biology
سال: 2017
ISSN: 1165-158X
DOI: 10.14715/cmb/2017.63.10.1